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Tim Young Selected Research

N- pyridazin- 3- yl- 4- (3- ((5- (trifluoromethyl)pyridin- 2- yl)oxy)benzylidene)piperidine- 1- carboxamide

9/2012An efficient randomised, placebo-controlled clinical trial with the irreversible fatty acid amide hydrolase-1 inhibitor PF-04457845, which modulates endocannabinoids but fails to induce effective analgesia in patients with pain due to osteoarthritis of the knee.
7/2011Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective fatty acid amide hydrolase inhibitor that reduces inflammatory and noninflammatory pain.

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Tim Young Research Topics

Disease

2Cystic Fibrosis (Mucoviscidosis)
10/2018 - 10/2018
2Infections
06/2018 - 01/2018
2Pain (Aches)
09/2012 - 07/2011
1Malnutrition (Nutritional Deficiencies)
08/2021
1Hemolysis
08/2021
1Fetal Growth Retardation (Intrauterine Growth Retardation)
10/2018
1Inflammation (Inflammations)
06/2018
1Congenital Heart Defects (Congenital Heart Defect)
01/2018
1Headache (Headaches)
10/2014
1Osteoarthritis
09/2012
1Knee Osteoarthritis
09/2012
1Nervous System Diseases (Neurological Disorders)
07/2011
1Weight Gain
07/2011
1Catalepsy
07/2011
1Disease Progression
11/2009

Drug/Important Bio-Agent (IBA)

3Biomarkers (Surrogate Marker)IBA
08/2021 - 01/2018
2ivacaftor drug combination tezacaftorIBA
10/2018 - 10/2018
2ChloridesIBA
10/2018 - 10/2018
2Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)IBA
10/2018 - 10/2018
2N- pyridazin- 3- yl- 4- (3- ((5- (trifluoromethyl)pyridin- 2- yl)oxy)benzylidene)piperidine- 1- carboxamideIBA
09/2012 - 07/2011
2EndocannabinoidsIBA
09/2012 - 07/2011
1EnzymesIBA
08/2021
1Edetic Acid (EDTA)FDA Link
08/2021
1VX-659IBA
10/2018
1elexacaftorIBA
10/2018
1Proteins (Proteins, Gene)FDA Link
06/2018
1Amino AcidsFDA Link
06/2018
1itaconic acidIBA
01/2018
1Indomethacin (Indometacin)FDA LinkGeneric
10/2014
1Fatty Acids (Saturated Fatty Acids)IBA
09/2012
1CannabinoidsIBA
09/2012
1Naproxen (Naprosyn)FDA LinkGeneric
09/2012
1AmidesIBA
09/2012
1fatty-acid amide hydrolase (fatty acid amide hydrolase)IBA
07/2011
1Dihydrotachysterol (AT 10)IBA
07/2011
1Freund's AdjuvantIBA
07/2011
1Iodoacetic AcidIBA
07/2011
1Cannabinoid Receptors (Cannabinoid Receptor)IBA
07/2011
1CarbonIBA
11/2009

Therapy/Procedure

1Heart Transplantation (Grafting, Heart)
01/2018
1Analgesia
09/2012
1Oral Administration
07/2011